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Chemical modification of L-asparaginase with a comb-shaped copolymer of polyethylene glycol derivative and maleic anhydride

✍ Scribed by Yoh Kodera; Hideki Tanaka; Ayako Matsushima; Yuji Inada


Book ID
115765193
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
357 KB
Volume
184
Category
Article
ISSN
0006-291X

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A series of polyethylene glycol grafted vinylpyrrolidonemaleic anhydride copolymers [P(VMP)] was synthesized by radical copolymerization of vinylpyrrolidone, maleic anhydride and polyethylene glycol maleic acid monoester. Escherichia coli L-asparaginase was chemically modified with these copolymers.