Chemical Modification of Hydrophobic Block in Poly(Ethylene Oxide) Poly(Caprolactone) Based Nanocarriers: Effect on the Solubilization and Hemolytic Activity of Amphotericin B
✍ Scribed by Arash Falamarzian; Afsaneh Lavasanifar
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 348 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
The aim of this study was to develop methoxy poly(ethylene oxide)‐b‐poly(ε‐caprolactone) (MePEO‐b‐PCL) containing stearyl (St) substituents on PCL, and assess the efficacy of nanocarriers formed from this structure in comparison to unmodified MePEO‐b‐PCL and those with carboxyl substitutes on PCL on the solubilization and delivery of Amphotericin B (AmB). Prepared block copolymers were characterized for their molecular weight by ^1^H NMR and gel permeation chromatography. The self‐assembly of synthesized MePEO‐b‐PStCL to spherical particles of nanometer size range was shown by dynamic light scattering as well as electron and atomic force microscopy. Encapsulated AmB showed a reduction in its hemolytic activity against rat red blood cells in comparison to the commercial formulation of AmB, Fungizone.
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