Chemical durability of Y2O3-Al2O3-SiO2 glasses for thein vivo delivery of beta radiation

✍ Scribed by Erbe, Erik M. ;Day, Delbert E.

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 756 KB
• Volume: 27
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/jbm.820271010

✦ Synopsis

Microspheres made from Y203-A1203-Si02 (YAS) glasses, which contain radioactive Y-90, are currently being used to treat liver cancer in humans, where their chemical durability is of prime importance. In deionized water or saline at 37"C, the weight percent Yttrium (Y) dissolved from eight different YAS glasses ranged from only 0.02-0.13% of the total Y present and their dissolution rate was barely measurable, 5 1.0 x g/cm2-min.

The most chemically durable YAS glass was l7YzO3-19A1203-64Si02, mol %. The small amount of Y released from microspheres, 25-35 pm diameter, of this glass after corrosion in saline or deionized water at 37°C was essentially the same as for bulk glass samples. Based on their excellent chemical durability, it is concluded that YAS glass microspheres are suitable for in vivo use.