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Chemical decay of an antibiotic inverts selection for resistance

โœ Scribed by Palmer, Adam C; Angelino, Elaine; Kishony, Roy

Book ID
109913655
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
44 KB
Volume
6
Category
Article
ISSN
1552-4450

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A strain of Escherichia coli containing a conditional drug dependent arginine auxotrophy was used to select for the loss of plasmid and/or transposon encoded kanamycin (Km) or streptomycin (Sm) resistance determinants. Because these determinants inactivate the corresponding drug thus eliminating dru