Chemical Constituents from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical-Scavenging Activities
✍ Scribed by Fang-Fang Zhong; Yu Chen; Guang-Zhong Yang
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- German
- Weight
- 190 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
A new bis‐xanthone (xanthone=9__H__‐xanthen‐9‐one), named bigarcinenone A (1) which is the first example of a bis‐xanthone with the xanthone–xanthone linkage between an aromatic C‐atom and a C~5~ side chain from a guttiferae plant, a new phloroglucinol (=benzene‐1,3,5‐triol) derivative, named garcinenone F (2), together with seven known xanthones were isolated from the bark of Garcinia xanthochymus. Their structures were elucidated by spectroscopic methods, especially 2D‐NMR techniques. Bigarcinenone A (1) exhibited potent antioxidant activity in the 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical‐scavenging test with a IC~50~ value of 9.2 μM, compared to the positive control, the well‐known antioxidant butylated hydroxytoluene (BHT) with a IC~50~ of 20 μM (Table 3).
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