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Chemical Constituents from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical-Scavenging Activities

✍ Scribed by Fang-Fang Zhong; Yu Chen; Guang-Zhong Yang


Publisher
John Wiley and Sons
Year
2008
Tongue
German
Weight
190 KB
Volume
91
Category
Article
ISSN
0018-019X

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✦ Synopsis


Abstract

A new bis‐xanthone (xanthone=9__H__‐xanthen‐9‐one), named bigarcinenone A (1) which is the first example of a bis‐xanthone with the xanthone–xanthone linkage between an aromatic C‐atom and a C~5~ side chain from a guttiferae plant, a new phloroglucinol (=benzene‐1,3,5‐triol) derivative, named garcinenone F (2), together with seven known xanthones were isolated from the bark of Garcinia xanthochymus. Their structures were elucidated by spectroscopic methods, especially 2D‐NMR techniques. Bigarcinenone A (1) exhibited potent antioxidant activity in the 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical‐scavenging test with a IC~50~ value of 9.2 μM, compared to the positive control, the well‐known antioxidant butylated hydroxytoluene (BHT) with a IC~50~ of 20 μM (Table 3).


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