Chemical Carcinogens as Frameshift Mutagens: Salmonella DNA Sequence Sensitive to Mutagenesis by Polycyclic Carcinogens

Cell-mediated mutagenesis in cultured ch

Cell-mediated mutagenesis in cultured chinese hamster cells by polycyclic hydrocarbons: Mutagenicity and DNA reaction related to carcinogenicity in a series of compounds

✍ Caroline B. Wigley; Robert F. Newbold; Jacqueline Amos; Peter Brookes 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 French ⚖ 598 KB

## Abstract Three potycyclic hydrocarbons, benz(__a__)anthracene, 3‐methylcholanthrene and 7,12‐dimethyl‐benz(__a__)anthracene, have been studied in a cell‐mediated mutagenesis system using BHK 21 cells to metabolize the hydrocarbons and V‐79 cells as targets for detecting induced cytotoxicity and