𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Chemical and statistical considerations in the determination of partition coefficients of weakly ionizable drugs and poisons

✍ Scribed by Kofi Opong-Mensah; Thomas W. Woller; Andrew O. Obaseki; William R. Porter


Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
878 KB
Volume
2
Category
Article
ISSN
0731-7085

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Statistical physics partitioning and cla
✍ S.E. Lokshtanov; S.V. Ivanov; A.A. Vigasin πŸ“‚ Article πŸ“… 2005 πŸ› Elsevier Science 🌐 English βš– 442 KB

This paper aims at elaborating rigorous criteria which make it possible to discriminate between true bound, quasibound, and free pair states for a system possessing a pronounced anisotropy of intermolecular interaction. The speculative statistical physics definition for various domains in the phase

Statistical determination of the average
✍ Henryk Mach; C.Russell Middaugh; Randolph V. Lewis πŸ“‚ Article πŸ“… 1992 πŸ› Elsevier Science 🌐 English βš– 780 KB

Spectroscopic measurement of protein concentration requires knowledge of the value of the relevant extinction coefficient. If the amino acid composition of a protein is known, however, extinction coefficients can be calculated approximately, provided that the values of the molar absorptivities for t

The effect of surface charge and partiti
✍ Nongnuch Pongcharoenkiat; Ganesan Narsimhan; Robert T. Lyons; Stanley L. Hem πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 137 KB πŸ‘ 1 views

Methylparaben (MP) was the model solute used to study the effect of surface charge on the rate of degradation in oil-in-water emulsions. The surface charge was varied by adding small amounts of phosphatidylglycerol (anionic) or stearylamine (cationic) to a standard intravenous lipid emulsion stabil

A priori prediction of tissue:plasma par
✍ Patrick Poulin; Frank-Peter Theil πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 374 KB πŸ‘ 3 views

The tissue:plasma (P t:p ) partition coefficients (PCs) are important drugspecific input parameters in physiologically based pharmacokinetic (PBPK) models used to estimate the disposition of drugs in biota. Until now the use of PBPK models in early stages of the drug discovery process was not possib