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Chemical and biological properties of 2,6-diisopropyl IDA labelled with 99mTc

✍ Scribed by B. Zmbova; D. Djokić; D. Ninković; V. Obradović; K. Kostić

Publisher
Elsevier Science
Year
1987
Weight
826 KB
Volume
38
Category
Article
ISSN
0883-2889

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✦ Synopsis

A procedure is described for the synthesis of 2,6-diisopropyl IDA (DISIDA) and for preparation of the radiopharmaceutical by "instant technique". The chemical parameters affecting the formation of the Sn(II)-DISIDA complex were also determined. Biological studies involved lyophylic measurements, determination of binding constants as well as rate of binding to proteins and biodistribution. Clinical investigation demonstrated good hepatobiliary features of this radiopharmaceutical.

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