✦ LIBER ✦

Chelation-or Non-Chelation-Control in Stereoselective Reactions of Titanium Reagents with Chiral Alkoxy Carbonyl Compounds

✍ Scribed by Prof. Dr. Manfred T. Reetz; Dipl.-Chem. Kurt Keßeler; Dipl.-Chem. Susi Schmidtberger; Dr. Bernd Wenderoth; Dr. Rainer Steinbach

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 292 KB
Volume: 22
Category: Article
ISSN: 0044-8249
DOI: 10.1002/anie.198315110

No coin nor oath required. For personal study only.

✦ Synopsis

Since Cram's pioneering workon chelation-control in Grignardtype of addition to chiral alkoxy carbonyl compounds/l/, a number of related reports have appeared. G ' s systematic studies concerning the relative merits of such classical reagents as RMgX, RLi and R CuLi deserve particular attention/2/.

Generally, these metals undergo more or less efficient chelation, as inferred from the stereochemical result. In this communication we apply the principle of variable adjustment of carbanion-selectivity by titanation/3/ in addition reactions of chiral alkoxy aldehydes and ketones. In particular, we show:

📜 SIMILAR VOLUMES

Chelation or Non-Chelation Control in St

Chelation or Non-Chelation Control in Stereoselective Reactions of Titanium Reagents with Chiral Alkoxycarbonyl Compounds

✍ Prof. Dr. Manfred T. Reetz; Kurt Kesseler; Susi Schmidtberger; Dr. Bernd Wendero 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 234 KB 👁 1 views

Stereoselectivity and Relative Reactivit

Stereoselectivity and Relative Reactivity in the Reaction of Alkyl Titanium and Zirconium Reagents with Carbonyl Compounds

✍ Prof. Dr. Manfred T. Reetz; Dipl.-Chem. Rainer Steinbach; Dipl.-Chem. Jürgen Wes 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 248 KB 👁 1 views