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Chelation of neurotoxic zinc levels does not improve neurobehavioral outcome after traumatic brain injury

✍ Scribed by Helen L. Hellmich; Kristine Eidson; Jeremy Cowart; Jeanna Crookshanks; Deborah K. Boone; Syed Shah; Tatsuo Uchida; Douglas S. DeWitt; Donald S. Prough

Book ID
116770512
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
331 KB
Volume
440
Category
Article
ISSN
0304-3940

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## Abstract Increasing evidence suggests a role for cyclooxygenase‐2 (COX‐2) in traumatic brain injury (TBI). In the present study, the role of COX‐2 in TBI was investigated using COX‐2 gene‐disrupted (COX‐2 null) mice and wild‐type (WT) controls that were subjected to the controlled cortical impac