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Chelation-Controlled Reduction: Stereoselective Formation of syn-1,3-Diols and Synthesis of Compactin and Mevinolin Lactone.

โœ Scribed by Arun K. Ghosh; Hui Lei


Publisher
John Wiley and Sons
Year
2003
Weight
371 KB
Volume
34
Category
Article
ISSN
0931-7597

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Highly Stereoselective Synthesis of syn-
โœ Judit Esteve; Sรฒnia Matas; Miquel Pellicena; Javier Velasco; Pedro Romea; Fรจlix ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 216 KB ๐Ÿ‘ 1 views

## Abstract A sequential transformation based on a titaniumโ€mediated aldol reaction from chiral ฮฑโ€__tert__โ€butyldimethylsilyloxy ketones followed by reduction of the resultant aldolates with LiBH~4~ provides a straightforward access to __syn__โ€1,3โ€diols. These diols, containing up to three new ster