Checkpoints controlling mitosis

✍ Scribed by Duncan J. Clarke; Juan F. Giménez-Abián

• Book ID: 102660606
• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 609 KB
• Volume: 22
• Category: Article
• ISSN: 0265-9247
• DOI: 10.1002/(sici)1521-1878(200004)22:4<351::aid-bies5>3.0.co;2-w

✦ Synopsis

Each year many reviews deal with checkpoint control. (1 ±5) Here we discuss checkpoint pathways that control mitosis. We address four checkpoint systems in depth: budding yeast DNA damage, the DNA replication checkpoint, the spindle assembly checkpoint and the mammalian G2 topoisomerase II-dependent checkpoint. A main focus of the review is the organization of these checkpoint pathways. Recent work has elucidated the order-of-function of several checkpoint components, and has revealed that the S phase, DNA damage and spindle assembly checkpoints each have at least two parallel branches. These steps forward have largely come from kinetic studies of checkpoint-defective mutants. BioEssays 22:351±363, 2000.