Synthesis of N-trifluoroacetyl-l-acosami
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István Pelyvás; Akira Hasegawa; Roy L. Whistler
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Article
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1986
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Elsevier Science
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English
⚖ 787 KB
A simple and efficient route to N-trifluoroacetyl-L-acosamine (13), N-trifluoroacetyl-L-daunosamine (12), and their 1-thio analogues (18 and 20) is described. Stereoselective reduction of oxime 5 with borane, followed by trifluoroacetylation resulted in the arabino methyl glycoside (8), which, on mi