Characterization of von willebrand factor in factor VIII concentrates
β Scribed by William A. Fricke; Mei-Ying Wong Yu
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 486 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0361-8609
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## Diagnosis of von Willebrand disease Type 2N (vWD 2N ), which mimics hemophilia A and its carrier state, is important for accurate genetic counseling and appropriate therapy. To make testing for the disorder more clinically applicable, we developed a simplified method for measurement of factor V
A patient with type 2N ("Normandy" variant) von Willebrands disease is described. Her von Willebrand factor level was borderline low, while her factor Vlll was markedly decreased to 7%. Her plasma von Wlliebrand factor demonstrated a decreased ability to complex with factor Vlll In vitro, binding le