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Characterization of valproic acid-initiated homologous recombination

✍ Scribed by Kevin Sha; Louise M. Winn

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 250 KB
Volume: 89
Category: Article
ISSN: 1542-9733
DOI: 10.1002/bdrb.20236

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## Abstract ## BACKGROUND Valproic acid (VPA) is widely used to treat epilepsy and bipolar disorder and is also a potent teratogen, but its teratogenic mechanisms are unknown. We have attempted to describe a fundamental role of the Polycomb group (Pc‐G) in VPA‐induced transformations of the axial

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