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Characterization of UDP-Glucuronosyltransferases Involved in Glucuronidation of Diethylstilbestrol in Human Liver and Intestine

โœ Scribed by Zhu, Liangliang; Ge, Guangbo; Liu, Yong; Guo, Zhimou; Peng, Chengcheng; Zhang, Feng; Cao, Yunfeng; Wu, Jingjing; Fang, Zhongze; Liang, Xinmiao; Yang, Ling

Book ID
118143938
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
468 KB
Volume
25
Category
Article
ISSN
0893-228X

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โœ Kristian Linnet ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 72 KB

Olanzapine is a widely used, newer antipsychotic agent, which is metabolized by various pathways: hydroxylation and N-demethylation by cytochrome P450, N-oxidation by flavin monooxygenase and direct glucuronidation. In vivo studies have pointed towards the latter pathway as being of major importance