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Characterization of two new alleles at the goat CSN1S2 locus

✍ Scribed by L. Ramunno; G. Cosenza; M. Pappalardo; E. Longobardi; D. Gallo; N. Pastore; P. Di Gregorio; A. Rando

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
183 KB
Volume
32
Category
Article
ISSN
0268-9146

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✦ Synopsis

Two novel alleles at the goat CSN1S2 locus have been identified: CSN1S2^F^ and CSN1S2^D^. Sequence analyses revealed that the CSN1S2^F^ allele is characterized by a G β†’ A transition at the 13th nucleotide in exon 3 changing the seventh amino acid of the mature protein from Val to Ile. The CSN1S2^D^ allele, apparently associated with a decreased synthesis of __Ξ±__s2‐casein, is characterized by a 106‐bp deletion, involving the last 11 bp of the exon 11 and the first 95 bp of the following intron. Methods (PCR–RFLP and PCR) for identification of carriers of these alleles have been developed.

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