Characterization of Toxaphene by High Resolution Gas Chromatography Combined with High Resolution Mass Spectrometry and Tandem Mass Spectrometry

✍ Scribed by F. J. Santos; M. T. Galceran; J. Caixach; J. Rivera; X. Huguet

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 270 KB
• Volume: 11
• Category: Article
• ISSN: 0951-4198
• DOI: 10.1002/(sici)1097-0231(19970228)11:4<341::aid-rcm832>3.0.co;2-n

✦ Synopsis

We examined the use of high resolution gas chromatography-electron ionization high resolution mass spectrometry (HRGC/EI-HRMS) in determining the toxaphene homologue distribution. Operating parameters such as electron energy, trap current and source temperature were optimized in order to obtain the maximum signal of the [M-C] + and [M-HCl] + • fragment ions of each homologue group. Internal interferences due to the fragment ions from the homologues with one and two additional chlorine atoms were eliminated using EI-HRMS at a resolving power of 10 000 or higher. Tandem mass spectrometry (EI-MS/MS) was used in the fragmentation studies. HRGC/EI-HRMS-selected ion monitoring (SIM) at a resolving power of 10 000 was used to determine the homologue distribution of a commercial toxaphene mixture. This technique gave detection limits of ppb level. The performance of HRGC/EI-HRMS-SIM was compared to HRGC/ECNI-MS using isobutane as a moderating gas.