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Characterization of topoisomerase II-DNA interaction and identification of a DNA-binding domain by ultraviolet laser crosslinking

✍ Scribed by Franki Hung; Dan Luo; Debra M. Sauvé; Mark T. Muller; Michel Roberge

Book ID: 115932025
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 605 KB
Volume: 380
Category: Article
ISSN: 0014-5793
DOI: 10.1016/0014-5793(96)00035-x

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## Abstract The location of __MLL__ translocation breakpoints within therapy‐related acute myeloid leukemia linked to drugs targeting Topoisomerase II and infant acute leukemia (IAL) are biased toward the intron 11–exon 12 region of __MLL__, although lacking a comprehensive explanation. To address