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Characterization of three transcriptional repressor sites within the 3′ untranslated region of the rat serine protease inhibitor 2.3 gene

✍ Scribed by Conception Paul; Anne-Emmanuelle Simar-Blanchet; Hyo-Sung Ro; Alphonse Le Cam

Book ID
114429195
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
448 KB
Volume
254
Category
Article
ISSN
1432-1327

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Chromosomal or allelic losses at 3p14 are common in a variety of human tumors, including those of the lung, breast, kidney, and head and neck. This suggests the existence of a tumor suppressor gene in this band. A promising candidate is the recently cloned FHIT gene, which spans the common fragile s