✦ LIBER ✦

Characterization of three HLA-DR beta genes isolated from an HLA-DR 3/4 insulin-dependent diabetic patient

✍ Scribed by D. Owerbach; C. Rich; K. Taneja

Book ID: 104745880
Publisher: Springer-Verlag
Year: 1986
Tongue: English
Weight: 636 KB
Volume: 24
Category: Article
ISSN: 0093-7711
DOI: 10.1007/bf00372296

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✦ Synopsis

Three HLA-DRfl genes were isolated from a Swedish HLA-DR3/4 insulin-dependent diabetes mellitus (IDDM) patient and characterized by restriction endonuclease mapping and nucleotide sequence analysis. Two out of the three DNA sequences differed from those of published DR[3-chain sequences. A DR/~-gene probe prepared from exon 4 and flanking sequences was used in a Southern blot analysis of blood donors' DNA and DNA from HLA-DR3/4 IDDM patients and HLA-DR-matched healthy control subjects. This probe differentiated HLA-DR3/4 IDDM patients and HLA-DRmatched controls in the Scandinavian population but not in the North American Caucasoid population.

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