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Characterization of the uptake of GABA, nipecotic acid and cis-4-OH-nipecotic acid in cultured neurons and astrocytes

โœ Scribed by Larsson, O.M.; Krogsgaard-Larsen, P.; Schousboe, A.

Book ID
122644108
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
622 KB
Volume
7
Category
Article
ISSN
0197-0186

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Uptake of GABA and nipecotic acid in ast
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โœ O.M. Larsson; L. Hertz; Dr. A. Schousboe ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 695 KB

The coupling ratio between sodium and GABA or the GABA analog, (RS)- nipecotic acid, in neuronal and glial uptake of GABA or nipecotic acid was investigated as a function of the morphological differentiation of these cell types in primary cultures. Both in neurons and astrocytes a high-affinity upta

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The influence of sodium ions on GABA uptake into neurons cultured from cerebral cortex was investigated at sodium concentrations ranging from 16 to 15 1 mh4. Sodium did not affect the K, for GABA uptake but the uptake rates as a function of the sodium concentration was sigmoid at all GABA concentrat