โ Scribed by Jennifer R. Potts; Kiaran Kirk; Philip W. Kuchel
No coin nor oath required. For personal study only.
We have refined the method for measuring the equilibrium exchange of the neutral phosphovl compound dimethyl methylphosphonate across the human red cell membrane using "P NMR spectroscopy. Using this improved technique we measured a permeability coefficient of dimethyl methylphosphonate of 9.47 f 1.01 x 10-5cms-' at a concentration of 1 6 4 m ~, at 25ยฐC. The transport at 25ยฐC was not saturable up to a concentration of 600 mM and was not inhibited by 4,4'-diisothiocyano-2,2'-disulfonic acid, pchloromercuriphenyl sulfonic acid, copper ions or phloretin, or by thiourea or urea at 16ยฐC. The permeability was enhanced by butanol and phloretin.
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