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Characterization of the transcriptional expression of Notch-1 signaling pathway members, Deltex and HES-1, in developing mouse thymocytes

✍ Scribed by Jung W. Choi; Christine Pampeno; Stanislav Vukmanovic; Daniel Meruelo

Book ID
117316249
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
319 KB
Volume
26
Category
Article
ISSN
0145-305X

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Gain-of-function mutations in Notch-1 are common in T-cell lymphoblastic leukemia (T-ALL), making this receptor a promising target for drugs such as gamma-secretase inhibitors (GSIs). However, GSIs seem to be active in only a small fraction of T-ALL cell lines with constitutive Notch-1 activity and