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Characterization of the slowly dissociable human growth hormone binding component of isolated rat hepatocytes

โœ Scribed by Donner, David B.; Casadei, Jan; Hartstein, Louise; Martin, Dwight; Sonenberg, Martin

Book ID
127061342
Publisher
American Chemical Society
Year
1980
Tongue
English
Weight
1018 KB
Volume
19
Category
Article
ISSN
0006-2960

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Fasting leads to an increase in insulin binding to isolated rat hepatocytes from 12 to 17%. This increase was accounted for by changes in the affinity of insulin receptors without alteration in their number. In contrast, the responsiveness of hepatocytes to insulin was markedly diminished in fasted