Characterization of the signaling pathway downstream p75 neurotrophin receptor involved in β-amyloid peptide-dependent cell death

Characterization of the toxic mechanism

Characterization of the toxic mechanism triggered by Alzheimer's amyloid-β peptides via p75 neurotrophin receptor in neuronal hybrid cells

✍ Emi Tsukamoto; Yuichi Hashimoto; Kohsuke Kanekura; Takako Niikura; Sadakazu Aiso 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 379 KB

## Abstract Neuronal pathology of the brain with Alzheimer's disease (AD) is characterized by numerous depositions of amyloid‐β peptides (Aβ). Aβ binding to the 75‐kDa neurotrophin receptor (p75NTR) causes neuronal cell death. Here we report that Aβ causes cell death in neuronal hybrid cells transf