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Characterization of the Rv3377c Gene Product, a Type-B Diterpene Cyclase, from the Mycobacterium tuberculosis H37 Genome

✍ Scribed by Chiaki Nakano; Tsutomu Hoshino

Book ID
101817521
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
231 KB
Volume
10
Category
Article
ISSN
1439-4227

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✦ Synopsis

Following a suggestion from Prof. (ETH-Hçnggerberg, Zürich) that Scheme 4 was incorrect, the authors carefully examined the relationship between the conformations of 5 and 7 and the NMR data (see Figure 1). They concluded that the assignments of 5 (6) and 7 (8) must be reversed; 3b-hydroxy derivative for 5 and 6, but 3a-hyroxy forms for 7 and 8.The authors apologize deeply for their mistakes.

📜 SIMILAR VOLUMES

Characterization of the Rv3377c Gene Pro
Characterization of the Rv3377c Gene Product, a Type-B Diterpene Cyclase, from the Mycobacterium tuberculosis H37 Genome
✍ Chiaki Nakano; Tsutomu Hoshino 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 555 KB

## Abstract __The Rv3377c gene from the__ Mycobacterium tuberculosis __H37 genome is specifically limited to those__ Mycobacterium __species that cause tuberculosis. We have demonstrated that the gene product of Rv3377c is a diterpene cyclase that catalyzes the formation of tuberculosinol from gera