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Characterization of the rhesus macaque (Macaca mulatta) equivalent ofHLA-F

✍ Scribed by Nel Otting; Ronald E. Bontrop

Publisher
Springer-Verlag
Year
1993
Tongue
English
Weight
393 KB
Volume
38
Category
Article
ISSN
0093-7711

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✦ Synopsis

Nucleotide sequence analysis of rhesus macaque major histocompatibility complex class I cDNAs allowed the identification of the orthologue of HLA-F, designated Mamu-F. Comparison of Mamu-F with earlier published human and chimpanzee orthologues demonstrated that these sequences share a high degree of similarity, both at the nucleotide and amino acid level, whereas a New World monkey (cotton-top tamarin) equivalent is more distantly related. Exon 7, encoding one of the cytoplasmatic domains, is absent for all primate Mhc-F cDNA sequences analyzed so far. In contrast to the human, chimpanzee, and rhesus macaque equivalents, the cotton-top tamarin Saoe-F gene seems to have accumulated far more nonsynomynous than synonymous differences.

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