Characterization of the RFX Complex and the RFX5(L66A) Mutant: Implications for the Regulation of MHC Class II Gene Expression †
✍ Scribed by Garvie, Colin W.; Stagno, Jason R.; Reid, Sarah; Singh, Ashina; Harrington, Erik; Boss, Jeremy M.
- Book ID
- 126323752
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 990 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0006-2960
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## Communicated by Henrik Dahl MHC class II deficiency is a severe primary immunodeficiency characterised by the absence of major histocompatibility complex class II (MHC-II) gene expression. It is genetically heterogeneous and can result from defects in at least four different trans-acting regula
## Abstract In this study the genetic control of major histocompatibility complex (MHC) class II gene expression during the transition from B cell to plasma cell has been analyzed. Class II molecules are not expressed in plasma cells because of an active suppression resulting in the abrogation of c