Characterization of the radioiodinated analogue of SCH 23390: In vitro and in vivo D-1 dopamine receptor binding studies
β Scribed by Robert D. McQuade; Richard Chipkin; Nordine Amlaiky; Marc Caron; Louis Iorio; Allen Barnett
- Book ID
- 118343247
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 784 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0024-3205
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π SIMILAR VOLUMES
Dopamine D 1 -receptor binding in the basal ganglia is differentially regulated by subtype nonspecific dopamine antagonists such as the antipsychotic, Fluphenazine. The purpose of the present study was to determine the relative contributions of D 1 and D 2 receptor systems in the regulation of basal
The dopamine D-1 receptor antagonist, SCH 23390 ((R)-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3- benzazepin-7-ol), was labelled by alkylation of the desmethyl compound SCH 24518 ((R)-(+)-8-chloro-2,3,4,5-tetrahydro-5-phenyl-1H-3-benzazepin-7- ol) with [11C]methyl iodide. A multivariate o