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Characterization of the NTRK1 Genomic Region Involved in Chromosomal Rearrangements Generating TRK Oncogenes

✍ Scribed by Angela Greco; Cristina Mariani; Claudia Miranda; Sonia Pagliardini; Marco A. Pierotti


Book ID
115611846
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
233 KB
Volume
18
Category
Article
ISSN
0888-7543

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The NTRK1 gene in the q arm of chromosome 1 encodes one of the receptors for the nerve growth factor and is frequently activated as an oncogene in papillary thyroid carcinomas. The activation is due to chromosomal rearrangements juxtaposing the NTRK1 tyrosine kinase domain to 58-end sequences from d