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Characterization of the liver cytosol antigen type 1 reacting with autoantibodies in chronic active hepatitis

✍ Scribed by Dr. Nisen Abuaf; Catherine Johanet; Pascale Chretien; Eric Martini; Emmanuelle Soulier; Syria Laperche; Jean Claude Homberg

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 837 KB
Volume: 16
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840160407

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✦ Synopsis

An autoantibody to liver cytosol was previously described in childhood autoimmune chronic active hepatitis type 2. The antigen, liver cytosol antigen type 1, was for the first time partially purified using gel filtration and ion exchange chromatography, and it was characterized using immunodiffusion, immunoblot and sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of the immunoprecipitate. Immunoblot detected a unique antigenic peptide at 62

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