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Characterization of the Ligand Binding Activities of Vitronectin: Interaction of Vitronectin with Lipids and Identification of the Binding Domains for Various Ligands Using Recombinant Domains †

✍ Scribed by Yoneda, Atsuko; Ogawa, Haruko; Kojima, Kyoko; Matsumoto, Isamu

Book ID
127016655
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
140 KB
Volume
37
Category
Article
ISSN
0006-2960

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✍ Gordon Royle; Gary Deng; Dietmar Seiffert; David J. Loskutoff 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 272 KB

Plasminogen activator inhibitor type-1 (PAI-1) is bound to vitronectin (VN) in plasma and in the extracellular matrix. We previously employed a domainswapping approach to show that the high-affinity binding site for PAI-1 in VN is contained within residues 12-30 in the amino-terminal somatomedin B (