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Characterization of the gastrointestinal microbiota in health and inflammatory bowel disease

โœ Scribed by Peter De Cruz; Lani Prideaux; Josef Wagner; Siew C. Ng; Chris McSweeney; Carl Kirkwood; Mark Morrison; Michael A. Kamm

Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
210 KB
Volume
18
Category
Article
ISSN
1078-0998

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โœฆ Synopsis

The enteric bacterial flora play a key role in maintaining health. Inflammatory bowel disease is associated with quantitative and qualitative alterations in the microbiota. Early characterization of the microbiota involved culture-dependent techniques. The advent of metagenomic techniques, however, allows for structural and functional characterization using culture-independent methods. Changes in diversity, together with quantitative alterations in specific bacterial species, have been identified. The functional significance of these changes, and their pathogenic role, remain to be elucidated.

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