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Characterization of the Cellular Localization, Expression Level, and Function of SNP Variants of MRP2/ABCC2

✍ Scribed by Masakazu Hirouchi; Hiroshi Suzuki; Masaya Itoda; Shogo Ozawa; Jun-ichi Sawada; Ichiro Ieiri; Kenji Ohtsubo; Yuichi Sugiyama


Book ID
111603578
Publisher
Springer US
Year
2004
Tongue
English
Weight
185 KB
Volume
21
Category
Article
ISSN
0724-8741

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Functional characterization of protein v
✍ Rudolf Arlanov; Andrew Porter; Dennis Strand; Rachel Brough; Darja Karpova; Rein πŸ“‚ Article πŸ“… 2012 πŸ› John Wiley and Sons 🌐 English βš– 596 KB

The multidrug resistance-associated protein 2 (MRP2/ABCC2) is involved in the efflux of endogenous and xenobiotic substrates, including several anticancer and antiviral drugs. The functional consequences of ABCC2 protein variants remain inconsistent, which may be due to shortcomings of the in vitro