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Characterization of the 12C4 survivin monoclonal antibody and insight into the expression of survivin in human adult tissues

✍ Scribed by B Spaulding; D Pan; A Ghadersohi; G Nielsen; S Jensen; F Gellert; X Ling; M Zhang; A Black; F Li

Book ID
108780235
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
868 KB
Volume
49
Category
Article
ISSN
0309-0167

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## Abstract BRCA1 is a multifunctional tumor‐suppressive protein. Many functional aspects of BRCA1 are not fully understood. We used a shRNA approach to probe the function of BRCA1 in human breast cancer cells. Knocking down BRCA1 expression by shRNA in the wild‐type BRCA1 human breast cancer MCF‐7