✦ LIBER ✦

Characterization of target antigens from anti-neutrophil cytoplasmic antibodies in autoimmune hepatitis type-I

✍ Scribed by Roland Kellner; Thomas Orth; PD Dr. Werner-Johannes Mayet

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 453 KB
Volume: 18
Category: Article
ISSN: 0173-0835
DOI: 10.1002/elps.1150180328

No coin nor oath required. For personal study only.

✦ Synopsis

The occurrence of anti-neutrophil cytoplasmic antibodies (ANCA) has been described in sera of patients with autoimmune hepatitis (AIH). The significance of this finding remains uncertain and the nature of the target antigen(s)

has not yet been defined. We studied 32 sera from patients with AIH type-I and prepared extracts of human neutrophils to identify the target antigen(s). A 43 kDa dominant immunoreactive protein was found and identified as the cytoskeletal component actin. Initial studies to define the antigenic determinants identified three different actin domains.

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Anti-neutrophil cytoplasmic antibodies in type 1 and 2 autoimmune hepatitis

✍ D Zauli; S Ghetti; A Grassi; C Descovich; F Cassani; G Ballardini; L Muratori; F 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 138 KB

Perinuclear anti-neutrophil cytoplasmic antibodies (pANCA) have been recently defined as the most sensitive autoantibody of type 1 autoimmune hepatitis (AIH-1). Their prevalence in type 2 autoimmune hepatitis (AIH-2) has not yet been evaluated. The aim of the present study was to verify the associat