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Characterization of pseudo-islets formed from pancreatic islet cell suspensions of neonatal rats

✍ Scribed by Schröder, D.; Wegner, U.; Besch, W.; Zühlke, H.


Book ID
122807870
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
933 KB
Volume
32
Category
Article
ISSN
0303-7207

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Islet cell lines were produced by retroviral transduction of SV-40 T antigen to monolayer cultures of neonatal rat islets. One line, RN0-11, showed evolution of phenotypes in vitro. It evolved from a non-hormone secreting cell line to an insulin secreting line. It further developed glucagon producin