Transforming growth factor P (TGFP) is a family of important regulators of chondrocyte growth and differentiation. Although TGFP has been detected in cartilage, the TGFj3 isoform5 expressed by chondrocytes and their regulation by growth factors are unknown. This study shows that human articular chon
✦ LIBER ✦
Characterization of proteoglycans synthesized by rabbit articular chondrocytes in response to transforming growth factor β (TGF β)
✍ Scribed by Nakanishi, Nobuki; Shneider, Neil A.; Axel, Richard
- Book ID
- 122101698
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 172 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1043-4666
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Rabbit articular chondrocytes were incubated with recombinant transforminggrowthiactor-p, (rhTGF-P,) and its effect on newly synthesized proteoglycan measured. rhTGF-P, stimulated proteoglycan synthesis at a concentration as low as 5 ngiml without further increases in radiosulfate incorporation up t