## Abstract Endogenous carcinogens arising from normal metabolism are known to cause modifications to DNA by reacting with bases to form adducts. Malondialdehyde is a well characterized endogenous carcinogen that forms an adduct with 2β²βdeoxyguanosine. This adduct has been detected in rat and human
Characterization of protein adducts formed by toxic alkaloids by nano-scale liquid chromatography with mass spectrometry
β Scribed by Chi-Hsien Chou; Lea-Yea Chuang; Wei-Lung Tseng; Chi-Yu Lu
- Book ID
- 115558999
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 984 KB
- Volume
- 47
- Category
- Article
- ISSN
- 1076-5174
- DOI
- 10.1002/jms.3083
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The sensitivity of mass spectrometry combined with the separatory power of high-performance liquid chromatography was used to investigate the venom of individual cone shells. This analysis has revealed that cone venoms contain a complex mixture of peptides which vary quantitatively and qualitatively