Characterization of poly(D,L-lactic acid) synthesized by direct melt polymerization and its application in Chinese traditional medicine compound prescription microspheres

Direct synthesis of poly(D,L-lactic acid

Direct synthesis of poly(D,L-lactic acid) by melt polycondensation and its application in drug delivery

✍ Yaoming Zhao; Zhaoyang Wang; Jun Wang; Hangzhen Mai; Bing Yan; Fan Yang 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 227 KB 👁 2 views

## Abstract Starting from D,L‐acid and SnCl~2~ as catalyst, poly(D,L‐lactic acid) (PDLLA) was directly synthesized by melt polycondensation. Under the appropriate conditions such as 0.5 wt % SnCl~2~, 170–180°C, 70 Pa, and 10 h, the viscosity‐average molecular weight (__M__~η~) of PDLLA was 4100 Da.