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Characterization of Osteogenesis Imperfecta Mutations in Type I Collagen: A Molecular Dynamics Study

โœ Scribed by Marlowe, Ashley E.; Yingling, Yaroslava G.


Book ID
119207757
Publisher
Biophysical Society
Year
2011
Tongue
English
Weight
37 KB
Volume
100
Category
Article
ISSN
0006-3495

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## Communicated by Richard G.H. Cotton Mutations in the type I collagen genes COL1A1 and COL1A2 are responsible for the dominantly inherited connective tissue disorder osteogenesis imperfecta (OI). The severity of OI is diverse, ranging from perinatal lethality to a very mild phenotype that is cha