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Characterization of Novel Fluorescent Ligands with High Affinity for D1 and D2 Dopaminergic Receptors

โœ Scribed by Frederick J. Monsma Jr.; Anne C. Barton; Hee Chol Kang; Diana L. Brassard; Richard P. Haugland; David R. Sibley

Book ID
111175348
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
428 KB
Volume
52
Category
Article
ISSN
0022-3042

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A series of 2,5-disubstituted-1H-pyrroles (4-18) has been prepared based on replacement of the amide of sultopride 1 by a pyrrole ring. Subsequent modification of the basic side chain gave compounds with high affinity for the dopamine D3 receptor. In addition, 12 and 17 were shown to be D3 antagonis