Characterization of neuronal regeneration in the abdominal ganglion ofAplysia californica
✍ Scribed by Hamilton, John F. ;Fredman, Steven M.
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 258 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0022-3034
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✦ Synopsis
The ability of neurons in the ab-56). More axonal regeneration was seen in the hemidominal ganglion of Aplysia to regenerate their axons ganglion ipsilateral to the branchial nerve. Regenerafollowing branchial nerve crush was studied using rettion after 32 days postlesion was 60 { 5% of controls rograde staining and intracellular dye injection. The in the ipsilateral hemiganglion, as opposed to 29 duration of the gill withdrawal reflex (GWR) was { 6% in the contralateral hemiganglion. Regeneration measured prior to and following nerve crush. Three of individual neurons was also demonstrated. Identidays after crushing the nerve, the duration of the gill fied neuron R2 was shown by intracellular dye injecwithdrawal reflex was reduced to 20% of control levtion and electrical stimulation of antidromic action els. There was rapid recovery 19 days after crushing potentials to have an axon in the branchial nerve in the branchial nerve. The GWR duration returned to all ganglia allowed to regenerate for longer than 32 control levels by postlesion days 25-27. Some of the days. These results indicate that in Aplysia, despite behavioral recovery can be attributed to axonal regenbehavioral recovery, complete axonal regeneration eration. Regeneration, as evidenced by retrograde does not occur in a large segment of the neurons in staining, was first observed by postlesion day 15. The the adult central nervous system. ᭧ 1998 John Wiley & number of stained neurons in ganglia with crushes