Characterization of mutant mice that express polyglutamine in cerebellar Purkinje cells
β Scribed by Miho Oue; Kazuhiro Mitsumura; Takashi Torashima; Chiho Koyama; Haruyasu Yamaguchi; Nobuhiko Furuya; Hirokazu Hirai
- Book ID
- 113504043
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 941 KB
- Volume
- 1255
- Category
- Article
- ISSN
- 0006-8993
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The distribution of cerebellar gangliosides was studied in adult (73 +/- 2 days) nervous (nr/nr) mutant mice which lose 50-90% of their Purkinje cells. This neuronal loss is associated with significant reductions in cerebellar weight and ganglioside concentration. The cerebellar dry weights (mg) and
## Abstract The Purkinje neuron, one of the most fascinating components of the cerebellar cortex, is involved in motor learning, motor coordination, and cognitive function. Purkinje cell protein 2 (Pcp2/L7) expression is highly restricted to Purkinje and retinal bipolar cells, where it has been exp