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Characterization of metabotropic glutamate receptors negatively linked to adenylyl cyclase in brain slices

✍ Scribed by A.A. Genazzani; G. Casabona; M.R. L'Episcopo; D.F. Condorelli; P. Dell'Albani; H. Shinozaki; F. Nicoletti

Book ID
115804007
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
658 KB
Volume
622
Category
Article
ISSN
0006-8993

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## Abstract Several excitatory amino acid ligands were found potently to inhibit forskolin‐stimulated cAMP accumulation in rat cultured cerebellar astrocytes: L‐cysteine sulfinic acid (L‐CSA) = L‐aspartate > L‐glutamate β‰₯ the glutamate uptake inhibitor, L‐PDC. This property did not reflect activati