Characterization of mature rat oligodendrocytes: a proteomic approach
โ Scribed by Debora Dumont; Jean-Paul Noben; Marjan Moreels; Joris Vanderlocht; Niels Hellings; Frank Vandenabeele; Ivo Lambrichts; Piet Stinissen; Johan Robben
- Book ID
- 111180195
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 896 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0022-3042
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Investigation into CNS demyelinating diseases, which usually occur in adults, can be facilitated by the use of a good in vitro model. We have established a methodology whereby oligodendrocytes from adult rat CNS can be cultured in vitro, and we have characterized these cultures morphologically and i
Mutations in the proteolipid protein gene (PLP/plp), which encodes the major intrinsic membrane protein in central nervous system (CNS) myelin, cause inherited dysmyelination in mammals. One of these mutants, the myelin-deficient (md) rat, has severe dysmyelination that is associated with oligodendr