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Characterization of intracellular opioid binding sites and G regulatory proteins in neonatal and adult rat brain

✍ Scribed by M. Szücs; W.T. Bem; S-C.J. Yeung; C.J. Coscia

Book ID
115885686
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
113 KB
Volume
183
Category
Article
ISSN
0014-2999

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Differential coupling of opioid binding
Differential coupling of opioid binding sites to guanosine triphosphate binding regulatory proteins in subcellular fractions of rat brain
✍ M. Szücs; C. J. Coscia 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 771 KB

In this study, we present evidence for the occurrence of p, 6, and K opioid binding sites in synaptic plasma membranes (SPM) and microsomes of rat brain. Binding to all three opioid classes was inhibited by 5'-guanylylimidodiphosphate (Gpp[NH]p) in SPM, while microsomal sites proved to be insensitiv