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Characterization of interleukin-7 and interleukin-7 receptor in the pathogenesis of rheumatoid arthritis

โœ Scribed by Sarah R. Pickens; Nathan D. Chamberlain; Michael V. Volin; Richard M. Pope; Nicholas E. Talarico; Arthur M. Mandelin II; Shiva Shahrara


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
920 KB
Volume
63
Category
Article
ISSN
0004-3591

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## Abstract The recently characterized receptor for interleukin (IL)โ€7 (ILโ€7R) includes a unique ฮฑ chain as well as a common ฮณ chain shared with the receptors for ILโ€2 and ILโ€4. Engagement of the ILโ€7R activates the intracellular enzyme phosphatidylinositol (PtdIns) 3โ€kinase but the mechanism of Pt