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Characterization of inhibitory T cells induced by an analog of type II collagen in an HLA-DR1 humanized mouse model of autoimmune arthritis

✍ Scribed by Masaru Kimata, David L Cullins, Monica L Brown…


Book ID
120706121
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
517 KB
Volume
14
Category
Article
ISSN
1478-6354

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## Abstract ## Objective Type II collagen (CII) is a candidate autoantigen implicated in the pathogenesis of rheumatoid arthritis (RA). Posttranslational glycosylation of CII could alter intracellular antigen processing, leading to the development of autoimmune T cell responses. To address this po